Abstract: Topical Application of Nitrosonifedipine, a Novel Free Radical Scavenger, Ameliorate the Ischemic Skin Flap Necrosis

ConClusions: Ex-vivo normothermic limb perfusion preserves limb physiology and function for at least 12 hours. Thermography and ICG angiography are valuable tools in the assessment of limb perfusion quality with the advantage of providing an immediate evaluation which allows for the visual identification of perfusion gradients and regions of mal-perfusion. Muscle contraction upon nerve stimulation, a uniform physiologic temperature and tissue oxygenation, and the distal dye distribution on angiography identify a successful perfusion. These methods may have important future implications on the decision to transplant or replant a perfused limb. Myoglobin and CK concentration increased in all limbs during ex vivo perfusion, but the functional significance of this is still to be determined.